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Division of Science, Mathematics, and Computing presents

The Molecular Signature of Hair-Cell Progenitors in the Zebrafish Lateral Line

Thursday, February 6, 2014

[The Molecular Signature of Hair-Cell Progenitors in the Zebrafish Lateral Line]
A lecture by Aaron Steiner, Candidate for the position in Biology

Hearing impairment is most frequently caused by the loss of sensory hair cells, which do not naturally regenerate in mammals. The zebrafish lateral line serves as an ideal model for studying hair-cell regeneration, in part because in this system have been described progenitors—called mantle cells—from which hair-cell precursors originate. I have produced zebrafish with fluorescently labeled mantle cells, devised a method to isolate these cells by flow cytometry, and analyzed their transcriptional makeup. I have further defined the temporal window during which mantle cells respond to hair-cell death, and identified genes that are activated and repressed in these cells during regeneration. My approach has implicated unexpected signaling pathways in hair-cell replenishment, and may contribute to the development of treatments for hearing loss.


Location: Reem-Kayden Center Laszlo Z. Bito '60 Auditorium