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Hello, The following event may be of interest to you: Cascade Reactions with Alkynes Friday, February 22, 2013 A lecture byJason AbramsCandidate for the Position in ChemistryThis talk seeks to highlight new routes toward the construction of the aryltetralignan podophyllotoxin (Figure 1). Podophyllotoxin (1) is a precursor for clinically employed chemotherapy drugs such as etoposide and teniposide, and itself exhibits a mechanistically understood antineoplastic effect. Understandably these architecturally intriguing compounds have gained the attention of the scientific community and have resulted in several syntheses. However, with poor solubility and increasing drug resistance, there exists a need to develop new complementary approaches towards these important therapeutic agents. In this regard, the synthetic route towards podophyllotoxin has been crafted to be flexible, and amenable to analog development. A common theme for the newly developed route involves exploitation of the unique reactivity of alkynes, by incorporating recently developed methods into novel reaction sequences. Beyond the preparation of an important natural product with antineoplastic activity, the rationale for research as highlighted in the talk is an expansion of the utility of a unique Pd(II)-catalyzed enyne cyclization method by highlighting its utility towards natural product synthesis. In addition to a first and second generation route towards the ABCD ring system of podophyllotoxin, proposed future plans will be discussed including podophyllotoxin end-game completion, modifications to the biologically crucial E-ring, elaboration of an unusual tetralone byproduct, among others. Location: RKC 115 Sponsor: Division of Science, Mathematics, and Computing Contact: Craig Anderson. E-mail: [email protected] Phone: 845-752-2356 If you would like to see more events please visit the following URL: http://www.bard.edu/academics/programs/science/calendar/