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Chemistry Program presents

Synthesis of Multiblock Dendrimers via Isocyanide Multicomponent Reactions

Tuesday, October 22, 2013

[Synthesis of Multiblock Dendrimers via Isocyanide Multicomponent Reactions]
A lecture by
Jonathan G. Rudick, Ph.D.
Assistant Professor, Department of Chemistry, Stony Brook University
Nanoparticles carrying three or four different cargos at their surface have emerged as leading solutions for targeted delivery of therapeutic and imaging agents. Enhanced permeation and retention of nanometer-sized materials in diseased tissues (e.g., tumors) offers a passive mechanism to improve the efficacy of drugs and imaging agents. Multivalent materials that accumulate in diseased tissues deliver locally high concentrations of the drug or imaging agent. Adding chemical markers to nanoparticles loaded with drugs or imaging agents offers a mechanism for selectively targeting the cargo to diseased tissues, and reduce side effects of the treatment. Biomedical technologies that combine targeting, therapeutic, and imaging modalities on a single theranostic nanoparticle are currently sought to simultaneously treat and image diseased tissues. A critical challenge for translating theranostic technologies based on polyvalent nanoparticles from the lab to the clinic is that each modality added to the nanoparticle creates heterogeneity and batch-to-batch variability of the product(s). We have developed a synthesis strategy to prepare a novel class of multivalent nanoparticles called multiblock dendrimers, which can incorporate three or four modalities and resolve the issues of heterogeneity and batch-to-batch variability. We further anticipate that this synthesis strategy will yield novel materials for use in “bottom-up” nanofabrication. The key to our approach is to synthesize the multiblock dendrimers from component dendrons via multicomponent reactions (e.g., the Passerini three-component reaction). The presentation will include a proof-of-concept for the synthesis strategy and report our progress toward multiblock dendrimers useful in biomedical and nanotechnology applications.


For more information, call 845-758-7900, or e-mail mclaughl@bard.edu.

Location: RKC 115