Dean of the College and Chemistry Program Present
Applying Novel Organometallic Methodology to the Total Synthesis of Bioactive Compounds
Friday, April 5, 2019
RKC 122
1:30 pm – 2:30 pm EDT/GMT-4
1:30 pm – 2:30 pm EDT/GMT-4
Stephanie Rugg, Alfred State College
Carbon-carbon bond formation is critical for the synthesis of biologically active compounds. Cross-electrophile coupling is a relatively new class of organometallic methodology that enables the formation of carbon-carbon bonds starting from commercially available compounds (e.g. organo halides). Part of this talk will describe the author’s work in development of cross-electrophile coupling with Michael acceptors.A research proposal involving rapid assembly of substituted enamides through activation of an amide N-H bond and subsequent coupling to an alkyne using catalysis will be described. Enamides are ubiquitously found in biologically active compounds (as well as in routes to their construction), but have not previously been synthesized using internal alkynes. This methodology will be applied in a second research proposal toward the synthesis of rigidiusculamide B, a novel cytotoxic agent versus human carcinoma cell lines.
For more information, call 845-752-2354, or e-mail [email protected].
Time: 1:30 pm – 2:30 pm EDT/GMT-4
Location: RKC 122